The science behind BioCentric Lighting™ lies in the understanding of human anatomy and our responsiveness to light. Increasing amounts of research reiterate the importance of daylight for our health, wellbeing and sleep. Cutting edge technological and medicinal research is therefore continuously integrated into our concept, in cooperation with our scientific advisory board. This is to ensure we deliver the best scientifically-based lighting environments for all needs.
Light affects us in mainly three ways; visually, emotionally and biologically. The visual dimension is the traditional one, affecting what we see and how we are seen. The emotional dimension has to do with how light affects our mood, energy and state of mind. Interest in the third dimension, focusing on how we are biologically affected by light, is rapidly increasing. This is due to more and more people realizing the potential in using light to enhance alertness, cognitive performance and the sleep/wake cycle. BioCentric Lighting™ is a game changer in effectively handling all three of these dimensions of light.
Chronobiology and personalized light
Chronobiology is gaining importance in the understanding of human physiology. The innate rhythmicity of biological functions, where most fluctuate according to a circadian rhythm, thus prepare the body for daily recurring events such as eating and sleeping. The pancreatic clock regulates insulin secretion and its response to glucose; the hepatic clock regulates glucose clearance, the skeletal muscle clock regulates metabolism and glucose uptake, and so on³⁶. The suprachiasmatic nucleus in the hypothalamus is the synchronizer for all of the clocks in the body. It adjusts the production of hormones such as melatonin and cortisol. The timing of these processes is collectively called our circadian rhythm. Recent evidence points to a genetic variability of clock genes associated with individual differences in sleep and circadian physiology and non-visual response to light³⁷.
Most people have a circadian rhythm that is slightly longer than 24 hours
LED & Light
Effects of Light
Light has a significant effect on biological functions and our daily routines, and is central to our well-being. Exposure to daylight affects our sleep quality, efficiency, alertness and similar other important factors for our health. Research has led to a number of exciting study results that form the basis of BioCentric Lighting™.
Light affects normal human physiology in a profound way such as sleep and growth. With light we can affect mood, improve sleep and treat depression. But light also has a direct alerting effect and can affect productivity, learning and memory consolidation.
Other effects of light on humans are diseases that demonstrate seasonal and diurnal patterns. Seasonal affective disorder (SAD) and acute myocardial infarction (AMI) are two examples, occurring in a higher frequency during the darker months of the year¹. Also several of the basic human behaviors and bodily physiology show a diurnal, in some cases even a seasonal, rhythm and are affected by light for their expression.
Daylight exerts an alerting effect on our brain. We spend more time indoors today than ever and see less daylight than we biologically need. BrainLit’s BioCentric Lighting™ System stimulates the natural production of the activation hormone cortisol during the day by mimicking variations of daylight indoors, improving cognition, drive and creativity.
Humans follow a sleep/wake cycle, making us alert at certain times of the day and sleepy at others. Light is a key factor influencing this cycle, also called the circadian rhythm. A disrupted circadian rhythm affects us negatively in many aspects, and may cause sleep disorders. BrainLit’s BioCentric Lighting™ System contributes in balancing the circadian rhythm.
BrainLit’s BioCentric Lighting™ System contribute in balancing level and timing of production of the activation hormone cortisol and the sleep hormone melatonin. The outcome is a balanced circadian rhythm, which improves wellness and stamina as a result of better sleep and higher alertness.
Stronger immune system
BrainLit’s BioCentric Lighting™ System contributes to a circadian rhythm in balance. By mimicking daylight indoors it benefits many physiological processes vital to our health, including the immune system, metabolism, blood pressure, heart rate and body temperature.
Sleep-related problems are very common in society today. Lack of sleep leads to poor judgment, increased impulsiveness and lack of memory. Sleep patterns are directly connected with our circadian rhythm. A summary of research shows that light can correct a disturbed circadian rhythm²⁰, ²¹. Light exposure in the evening/early night shifts the melatonin onset to a later hour the next night, and light in early morning pushes the melatonin onset to an earlier hour the following night¹³. The strength of the synchronization depends on the light distribution and on the time of exposure²². An improved circadian rhythm is associated with improved sleep and reduced depressive symptoms²³.
Light has been used to treat depression for many years²⁴,²⁵. Published studies also show that a combination of pharmacological therapy and light is more effective than psychopharma alone, and chronobiological therapy is advancing²⁶. Similarly, daylight exposure has been used to reduce depression symptoms in individuals with dementia, a group that is largely affected by depression²⁷. Seasonal depression seems to be equally effective treated with blue-enriched white light at 750 lux as a standard bright lux at 10 000 lux²⁸.
Myopia is characterized by a growth of the eye where the eye is becoming too long in relation to the optics of the eye, placing the image in front of the retina. In a recently published report, light intensity and spectra were shown to affect the growth of the eye in an animal model³³. In another recent report, it was found that time spent outdoors prevents the development of myopia³⁴. In yet another study, it was also shown that time and intensity of light is crucial for the development of myopia³⁵. Receiving less than 40 min of bright daily light (> 1,000 lux) could predispose to faster growth, and it was speculated whether there is a minimum amount of light required to reduce growth.
Light affects our alertness⁶. Exposure to blue-enriched white light has an awakening effect³ and monochromatic blue light (420 nm) induce greater alertness compared to light with longer wavelengths, which is apparent also after long time exposure⁷. It is speculated whether this effect at daytime might be mediated via direct intrinsically photoreceptive retinal ganglion cells’ projections to the thalamic regions in the brain⁷.
Blue light seems to improve cognition⁸ and positively affect long time memory consolidation⁹. Also, blue light exposure among office workers has been shown to have positive long-term effects on productivity and concentration¹⁰, ¹¹.
Lower mood is an effect of poor lighting¹. In a population-based study in Finland, self-reported inadequate indoor illumination is associated with mental ill-being². In the same study, it was found that the negative effect of poor lighting is even more significant than the positive effect gained from regular physical exercise². On the other hand, light can also enhance mood. Blue-toned white light has a direct mood enhancing effect³ and several studies indicate that dawn simulations in the morning improve the subjective perception of well-being⁴.
The importance of adequate lighting in schools and its effect on well-being is important to reduce children’s level of stress. A group of Swedish researchers have argued for better lighting conditions to improve school environments⁵.
Effect of light dependents
- Length stimuli
- Previous light history
- Other influences such as food and excercise
Positive effects of the right light
1. Küller R, Ballal S, Laike T, Mikellides B, Tonello G. Ergonomics. 2006 Nov 15;49(14):1496-507.
2. Grimaldi S, Partonen T, Saarni SI, Aromaa A, Lönnqvist J. Health Qual Life Outcomes. 2008 Aug 1;6:56. doi: 10.1186/1477-7525-6-56.
3. Choi K, Shin C, Kim T, Chung HJ, Suk HJ. Sci Rep. 2019 Jan 23;9(1):345. doi: 10.1038/s41598-018-36791-5.
4. Gabel V, Maire M, Reichert CF, Chellappa SL, Schmidt C, Hommes V, Viola AU, Cajochen C. Chronobiol Int. 2013 Oct;30(8):988-97. doi: 10.3109/07420528.2013.793196. Epub 2013 Jul 10.
5 . NyTeknik, Debate. 23 juni 2015
6. Figueiro MG, Nagare R, Price L. Light Res Technol. 2018;50(1):38-62
7. Rahman SA, St Hilaire MA, Lockley SW. Physiol Behav. 2017 Aug 1;177:221-229. doi: 10.1016/j.physbeh.2017.05.002. Epub 2017 May 1.
8. Lehrl S, Gerstmeyer K, Jacob JH, Frieling H, Henkel AW, Meyrer R, Wiltfang J, Kornhuber J, Bleich S. J Neural Transm (Vienna). 2007;114(4):457-60
9. Alkozei A, Smith R, Dailey NS, Bajaj S, Killgore WDS. PLoS One. 2017 Sep 18;12(9):e0184884.
10. Viola AU, James LM, Schlangen LJ, Dijk DJ. Scand J Work Environ Health. 2008 Aug;34(4):297-306
11. Conference paper: 2002 ACEEE Summer Study on Energy Efficiency in Buildings, Volume: 8
12. Czeisler CA, Duffy JF, Shanahan TL, Brown EN, Mitchell JF, Rimmer DW, Ronda JM, Silva EJ, Allan JS, Emens JS, Dijk DJ, Kronauer RE. Science. 1999 Jun 25;284(5423):2177-81
13. Duffy JF, Czeisler CA. Sleep Med Clin. 2009 Jun;4(2):165-177
14. Boivin DB, Tremblay GM, James FO. Sleep Med. 2007 Sep;8(6):578-89. Epub 2007 May 3. Review
15. Zeitzer JM, Khalsa SB, Boivin DB, Duffy JF, Shanahan TL, Kronauer RE, Czeisler CA. Am J Physiol Regul Integr Comp Physiol. 2005 Sep;289(3):R839-44
16. Berson DM, Dunn FA, Takao M. Science. 2002 Feb 8;295(5557):1070-3
17. Reppert SM, Weaver DR. Nature. 2002 Aug 29;418(6901):935-41. Review.
18. Skene DJ, Skornyakov E, Chowdhury NR, Gajula RP, Middleton B, Satterfield BC, Porter KI, Van Dongen HPA, Gaddameedhi S. Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):7825-7830
19. Panda S ”The circadian code” ISBN 978-1-63565-243-7
20. Dautovich ND, Schreiber DR, Imel JL, Tighe CA, Shoji KD, Cyrus J, Bryant N, Lisech A, O’Brien C, Dzierzewski JM. Sleep Health. 2019 Feb;5(1):31-48
21. Wright KP Jr, McHill AW, Birks BR, Griffin BR, Rusterholz T, Chinoy ED. Curr Biol. 2013 Aug 19;23(16):1554-8
22. Wright KP Jr, Gronfier C, Duffy JF, Czeisler CA. J Biol Rhythms. 2005 Apr;20(2):168-77
23. Figueiro MG, Steverson B, Heerwagen J, Kampschroer K, Hunter CM, Gonzales K, Plitnick B, Rea MS. Sleep Health. 2017 Jun;3(3):204-215
24. Pail G, Huf W, Pjrek E, Winkler D, Willeit M, Praschak-Rieder N, Kasper S. Neuropsychobiology. 2011;64(3):152-62
25. Golden RN, Gaynes BN, Ekstrom RD, Hamer RM, Jacobsen FM, Suppes T, Wisner KL, Nemeroff CB. Am J Psychiatry. 2005 Apr;162(4):656-62
26. Dallaspezia S, Suzuki M, Benedetti F. Curr Psychiatry Rep. 2015 Dec;17(12):95
27. Konis K Buliding and Env. 2018 112-123
28. Meesters Y, Dekker V, Schlangen LJ, Bos EH, Ruiter MJ. BMC Psychiatry. 2011 Jan 28;11:17
29. Ostrin LA, Abbott KS, Queener HM. Ophthalmic Physiol Opt. 2017 Jul;37(4):440-450
30. Münch M, Nowozin C, Regente J, Bes F, De Zeeuw J, Hädel S, Wahnschaffe A, Kunz D. Neuropsychobiology. 2016;74(4):207-218
31. Kozaki T, Kubokawa A, Taketomi R, Hatae K. J Physiol Anthropol. 2015 Jul 4;34:27
32. Rångtell FH, Ekstrand E, Rapp L, Lagermalm A, Liethof L, Búcaro MO, Lingfors D, Broman JE, Schiöth HB, Benedict C. Sleep Med. 2016 Jul;23:111-118
33. Troilo D, Smith EL 3rd, Nickla DL, Ashby R, Tkatchenko AV, Ostrin LA, Gawne TJ, Pardue MT, Summers JA, Kee CS, Schroedl F, Wahl S, Jones L. Invest Ophthalmol Vis Sci. 2019 Feb 28;60(3):M31-M88
34. Rose KA, French AN, Morgan IG. Asia Pac J Ophthalmol (Phila). 2016 Nov/Dec;5(6):403-410. Review
35. Read SA, Collins MJ, Vincent SJ. Invest Ophthalmol Vis Sci. 2015 Oct;56(11):6779-87
36. Johnston JD, Ordovás JM, Scheer FA, Turek FW. Adv Nutr. 2016 Mar 15;7(2):399-406
37. Archer SN, Schmidt C, Vandewalle G, Dijk DJ. Sleep Med Rev. 2018 Aug;40:109-126
38. McKenna H, van der Horst GTJ, Reiss I, Martin D. Crit Care. 2018 May 11;22(1):124